Synthesis, Structure−Activity Relationships, and In Vivo Evaluation of N3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists-Reference-Cited by-同舟云学术

Synthesis, Structure−Activity Relationships, and In Vivo Evaluation of N3-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists

Published:2009-06-24 Issue:14 Volume:52 Page:4173-4191
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hartz Richard A.¹,Ahuja Vijay T.¹,Arvanitis Argyrios G.¹,Rafalski Maria¹,Yue Eddy W.¹,Denhart Derek J.¹,Schmitz William D.¹,Ditta Jonathan L.¹,Deskus Jeffrey A.¹,Brenner Allison B.¹,Hobbs Frank W.¹,Payne Joseph¹,Lelas Snjezana²,Li Yu-Wen²,Molski Thaddeus F.²,Mattson Gail K.²,Peng Yong²,Wong Harvey³,Grace James E.³,Lentz Kimberley A.³,Qian-Cutrone Jingfang³,Zhuo Xiaoliang³,Shu Yue-Zhong³,Lodge Nicholas J.²,Zaczek Robert²,Combs Andrew P.¹,Olson Richard E.¹,Bronson Joanne J.¹,Mattson Ronald J.¹,Macor John E.¹

Affiliation:

1. Neuroscience Discovery Chemistry

2. Neuroscience Discovery Biology

3. Pharmaceutical Candidate Optimization

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900301y

Reference53 articles.

1. Small Molecule Antagonists of the Corticotropin Releasing Factor (CRF)Receptor: Recent Medicinal Chemistry Developments

2. The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders

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