Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy
Author:
Affiliation:
1. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx9003243
Reference46 articles.
1. Lamotrigine-Associated Rash: Risk/Benefit Considerations in Adults and Children
2. Safety of Long-Term Lamotrigine in Epilepsy
3. Lamotrighe-Induced Severe Cutaneous Adverse Reactions
4. Mechanisms of Idiosyncratic Hypersensitivity Reactions to Antiepileptic Drugs
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