Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity-Reference-Cited by-同舟云学术

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Published:2008-04-15 Issue:9 Volume:51 Page:2758-2765
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miranda Les P.¹,Winters Katherine A.¹,Gegg Colin V.¹,Patel Ankita¹,Aral Jennifer¹,Long Jason¹,Zhang Jingwen¹,Diamond Stephanie¹,Guido Mark¹,Stanislaus Shanaka¹,Ma Mark¹,Li Hongyan¹,Rose Mark J.¹,Poppe Leszek¹,Véniant Murielle M.¹

Affiliation:

1. Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics & Drug Metabolism, Metabolic Disorders, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701522b

Reference54 articles.

1. The Glucagon-Like Peptides

2. Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

3. Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans

4. New Horizons in Diabetes Therapy

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