Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor-Reference-Cited by-同舟云学术

Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor

Published:2014-07-17 Issue:9 Volume:5 Page:968-972
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Benedetti Fabio¹,Berti Federico¹,Campaner Pietro¹,Fanfoni Lidia¹,Demitri Nicola¹,Olajuyigbe Folasade M.¹²,De March Matteo¹,Geremia Silvano¹

Affiliation:

1. Department of Chemical and Pharmaceutical Sciences, Centre of Excellence in Biocrystallography, University of Trieste, Via Giorgeri 1, 34127 Trieste, Italy

2. Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure 340001, Ondo State, Nigeria

Funder

Abdus Salam International Centre for Theoretical Physics

Friuli-Venezia-Giulia region

Schlumberger Foundation for Faculty

University of Trieste

MIUR

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500092e

Reference29 articles.

1. Survival trends in critically ill HIV-infected patients in the highly active antiretroviral therapy era

2. Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance

3. Development of Protease Inhibitors and the Fight with Drug‐Resistant HIV‐1 Variants

4. Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update

5. Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors

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