Design and Quantitative Structure−Activity Relationship of 3-Amidinobenzyl-1H-indole-2-carboxamides as Potent, Nonchiral, and Selective Inhibitors of Blood Coagulation Factor Xa-Reference-Cited by-同舟云学术

Design and Quantitative Structure−Activity Relationship of 3-Amidinobenzyl-1H-indole-2-carboxamides as Potent, Nonchiral, and Selective Inhibitors of Blood Coagulation Factor Xa

Published:2002-05-18 Issue:13 Volume:45 Page:2749-2769
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Matter Hans¹,Defossa Elisabeth¹,Heinelt Uwe¹,Blohm Peter-Michael¹,Schneider Detlev¹,Müller Andrea¹,Herok Silke¹,Schreuder Herman¹,Liesum Alexander¹,Brachvogel Volker¹,Lönze Petra¹,Walser Armin¹,Al-Obeidi Fahad¹,Wildgoose Peter¹

Affiliation:

1. Aventis Pharma Deutschland GmbH, DI&A, Molecular Modeling, Medicinal Chemistry, Structural Biology, DG Thrombosis and Degenerative Joint Diseases, Building G 878, D-65926 Frankfurt am Main, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0111346

Reference93 articles.

1. Hemostasis and Thrombosis: Basic Principles and Clinical Practice; Coleman, R. W., Marder, V. J., Salzman, E. W., Eds; J. B. Lippincott: Philadelphia, PA, 1994.

2. The coagulation cascade: initiation, maintenance, and regulation

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