Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin-Reference-Cited by-同舟云学术

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Structural Basis of Serine/Threonine Phosphatase Inhibition by the Archetypal Small Molecules Cantharidin and Norcantharidin

Published:2009-07-14 Issue:15 Volume:52 Page:4838-4843
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bertini I.¹²,Calderone V.¹,Fragai M.¹³,Luchinat C.¹³,Talluri E.¹

Affiliation:

1. Magnetic Resonance Center (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

2. Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy

3. Department of Agricultural Biotechnology, University of Florence, Via Maragliano 75-77, 50144 Florence, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900610k

Reference55 articles.

1. Cantharidin-binding protein: identification as protein phosphatase 2A.

2. Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells

3. Molecular modes of action of cantharidin in tumor cells

4. Molecular biology of cantharidin in cancer cells

Cited by 65 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cantharidin Inhibits Osteosarcoma Cell Proliferation and Metastasis through the FOXO3A/METTL14/Vimentin Pathway;J BIOL REG HOMEOS AG;2024

2. Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer;Cell Chemical Biology;2023-10

3. Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR;Journal of Translational Medicine;2023-09-05

4. Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation;Frontiers in Cell and Developmental Biology;2023-06-12

5. Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery;European Journal of Medicinal Chemistry;2023-06

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