4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships-Reference-Cited by-同舟云学术

4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships

Published:1998-07-01 Issue:16 Volume:41 Page:2946-2959
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pirotte Bernard¹,Podona Tchao¹,Diouf Ousmane¹,de Tullio Pascal¹,Lebrun Philippe¹,Dupont Léon¹,Somers Fabian¹,Delarge Jacques¹,Morain Philippe¹,Lestage Pierre¹,Lepagnol Jean¹,Spedding Michael¹

Affiliation:

1. Laboratoire de Chimie Pharmaceutique, Université de Liège, 3, rue Fusch, B-4000 Liège, Belgium, Laboratoire de Pharmacodynamie et de Thérapeutique, Université Libre de Bruxelles, 808, route de Lennik, B-1070 Bruxelles, Belgium, Laboratoire de cristallographie, Université de Liège, Sart Tilman, B-4000 Liège, Belgium, and Institut de Recherches Servier, 125, Chemin de Ronde, F-78290 Croissy-sur-Seine, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970694v

Reference42 articles.

1. Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure

2. The Metabotropic Glutamate Receptors

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