Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives-Reference-Cited by-同舟云学术

Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

Published:2014-05-30 Issue:12 Volume:79 Page:5697-5709
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Ghosh Arun K.¹,Chen Zhi-Hua¹,Effenberger Kerstin A.²,Jurica Melissa S.²

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 4790, United States

2. Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo500800k

Reference62 articles.

1. New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

2. New Antitumor Substances, FR901463, FR901464 and FR901465. II. Activities against Experimental Tumors in Mice and Mechanism of Action.

3. New Antitumor Substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465.

4. Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes

5. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

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