1. Department of Medical Biosciences, Clinical Chemistry, Umeå University, SE-90185, Umeå, Sweden, Research Group of Chemometrics, Department of Chemistry, Umeå University, SE-90187, Umeå, Sweden, Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Umeå University, SE-90187, Umeå, Sweden, and Department of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China