1. Discovery Research Oncology, Department of Chemistry, Pharmacia Corporation, Viale Pasteur 10, 20014 Nerviano, Italy, San Raffaele Scientific Institute, via Olgettina 58, 20132 Milano, Italy, Bioindustry Park del Canavese Spa, Via Ribes 5, 10010 Colleretto Giacosa, Italy, San Raffaele University, via Olgettina 58, 20132 Milano, Italy, and Dulbecco Telethon Institute, c/o San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy