Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases-Reference-Cited by-同舟云学术

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Published:2012-01-17 Issue:2 Volume:55 Page:961-965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thaher Bassam Abu¹,Arnsmann Martina²,Totzke Frank³,Ehlert Jan E.³,Kubbutat Michael H. G.³,Schächtele Christoph³,Zimmermann Markus O.⁴,Koch Pierre²,Boeckler Frank M.⁴,Laufer Stefan A.²

Affiliation:

1. Faculty of Science, Chemistry Department, Islamic University of Gaza, Gaza Strip, Palestine

2. Chair Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany

3. ProQinase GmbH, Breisacher Strasse 117, 79106 Freiburg, Germany

4. Laboratory for Molecular Design and Pharmaceutical Biophysics, Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, 72076 Tübingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201391u

Reference20 articles.

1. Palladium-Catalyzed Coupling of Pyrazole Triflates with Arylboronic Acids

2. Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity: A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles

3. Adams, J. L.; Gallagher, T. F.; Lee, J.Imidazole derivatives and their use as cytokine inhibitors. (SmithKline Beecham Corp., USA. 1993-US674[9314081], 70. WO. 13-1-1993.

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