Pyrimidine-2,4,6-trione Derivatives and Their Inhibition of Mutant SOD1-Dependent Protein Aggregation. Toward a Treatment for Amyotrophic Lateral Sclerosis-Reference-Cited by-同舟云学术

Pyrimidine-2,4,6-trione Derivatives and Their Inhibition of Mutant SOD1-Dependent Protein Aggregation. Toward a Treatment for Amyotrophic Lateral Sclerosis

Published:2011-03-04 Issue:7 Volume:54 Page:2409-2421
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xia Guoyao¹,Benmohamed Radhia²,Kim Jinho³,Arvanites Anthony C.²,Morimoto Richard I.⁴,Ferrante Robert J.³,Kirsch Donald R.²,Silverman Richard B.¹⁵

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States

2. Cambria Pharmaceuticals, Cambridge, Massachusetts 02142, United States

3. Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, United States, and Department of Neurology, Laboratory Medicine and Pathology, and Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, United States

4. Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208-3500, United States

5. Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101549k

Reference22 articles.

1. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

2. The epidemiology of motor neuron diseases: a review of recent studies

3. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy?

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