Accurate Mass Liquid Chromatography/Mass Spectrometry on Orthogonal Acceleration Time-of-Flight Mass Analyzers Using Switching between Separate Sample and Reference Sprays. 1. Proof of Concept

Author:

Eckers Christine1,Wolff Jean-Claude1,Haskins Neville J.1,Sage Ashley B.1,Giles Kevin1,Bateman Robert1

Affiliation:

1. SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, U.K., and Micromass UK Ltd., Floats Road, Wythenshawe, Manchester, M23 9LZ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference10 articles.

1. The use of liquid chromatography combined with a quadrupole time-of-flight analyser for the identification of trace impurities in drug substance

2. Exact mass measurement of product ions for the structural elucidation of drug metabolites with a tandem quadrupole orthogonal-acceleration time-of-flight mass spectrometer

3. Dresch, T.; Keefe, T.; Park, M.Proceedings of the 47th ASMS Conference onMass Spectrometry and Allied Topics,Dallas, TX, June 13−18, 1999; pp 1865−1866.

4. Andrien, B. A.; Whitehouse, C.; Sansone, M. A.Proceedings of the 46th ASMSConference on Mass Spectrometry and Allied Topics,Orlando, FL, May 31−June 4, 1998; p 889.

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