Understanding the Excitation Wavelength Dependence and Thermal Stability of the SARS-CoV-2 Receptor-Binding Domain Using Surface-Enhanced Raman Scattering and Machine Learning

Author:

Zhang Kunyan1ORCID,Wang Ziyang12ORCID,Liu He3,Perea-López Néstor45,Ranasinghe Jeewan C.12,Bepete George345ORCID,Minns Allen M.67,Rossi Randall M.7,Lindner Scott E.67,Huang Sharon X.8,Terrones Mauricio345910ORCID,Huang Shengxi12ORCID

Affiliation:

1. Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

2. Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005, United States

3. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

4. Department of Physics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

5. Center for 2-Dimensional and Layered Materials, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

6. Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

7. Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

8. College of Information Sciences and Technology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

9. Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

10. Research Initiative for Supra Materials, Shinshu University, 4-17-1 Wakasato, Nagano 380-8553, Japan

Funder

Pennsylvania State University

Johnson and Johnson

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Biotechnology,Electronic, Optical and Magnetic Materials

Reference57 articles.

1. Ortaliza, J.; Orgera, K.; Amin, K.; Cox, C. COVID-19 Continues To Be a Leading Cause of Death in the U.S. in September 2021. https://www.healthsystemtracker.org/brief/covid19-and-other-leading-causes-of-death-in-the-us/ (accessed Nov 18, 2021).

2. Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

3. The SARS-CoV-2 Vaccine Pipeline: an Overview

4. A systematic review of SARS-CoV-2 vaccine candidates

5. Structural basis of receptor recognition by SARS-CoV-2

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