A Monofunctional Derivative of Melphalan: Preparation, DNA Alkylation Products, and Determination of the Specificity of Monoclonal Antibodies That Recognize Melphalan−DNA Adducts-Reference-Cited by-同舟云学术

A Monofunctional Derivative of Melphalan: Preparation, DNA Alkylation Products, and Determination of the Specificity of Monoclonal Antibodies That Recognize Melphalan−DNA Adducts

Published:1998-09-12 Issue:10 Volume:11 Page:1162-1168
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Tilby Michael J.¹,McCartney Hazel¹,Gould Katherine A.¹,O'Hare C. Caroline¹,Hartley John A.¹,Hall Andrew G.¹,Golding Bernard T.¹,Lawley Philip D.¹

Affiliation:

1. Leukaemia Research Fund Laboratory and Department of Chemistry, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K., CRC Drug-DNA Interactions Research Group, Department of Oncology, University College London Medical School, London W1P 8BT, U.K., and Department of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx980129a

Reference29 articles.

1. International Agency for Research on Cancer (1987)IARC monographs on the evaluation of carcinogenic risks to humans. Supplement 7, pp 39−43, International Agency for Research on Cancer, Lyon, France.

2. DNA adducts from chemotherapeutic agents

3. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

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