On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA-Reference-Cited by-同舟云学术

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

Published:2018-04-03 Issue:5 Volume:12 Page:4787-4795
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Kulkarni Jayesh A.¹^ORCID,Darjuan Maria M.¹,Mercer Joanne E.²,Chen Sam¹³^ORCID,van der Meel Roy¹⁴,Thewalt Jenifer L.²^ORCID,Tam Yuen Yi C.¹³,Cullis Pieter R.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada

2. Department of Physics, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada

3. Integrated Nanotherapeutics, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada

4. Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands

Funder

Canadian Institutes of Health Research

British Columbia Innovation Council

Natural Sciences and Engineering Research Council of Canada

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.8b01516

Reference25 articles.

1. Advances in the delivery of RNA therapeutics: from concept to clinical reality

2. Lipid Nanoparticle Systems for Enabling Gene Therapies

3. Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

4. Alnylam and Sanofi Report Positive Topline Results from Apollo Phase 3 Study of Patisiran in Hereditary ATTR (hATTR) Amyloidosis Patients with Polyneuropathy. http://www.businesswire.com/news/home/20170920005628/en/, 2017, accessed Jan 11, 2018.

5. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

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