Intestinal Villi-Inspired Mathematically Base-Layer Engineered Microneedles (IMBEMs) for Effective Molecular Exchange during Biomarker Enrichment and Drug Deposition in Diversified Mucosa

Author:

Gong Yusheng12,Tong Shuai3,Li Xixuan4,Chen Xiuli12,Liu Yushuang5,Li Nan5,Xu Jiarong12,Xu Rengui6,Guo Yusong5,Xiao Fei7ORCID,Chen Xiaoyuan891011ORCID,Chen Wei12ORCID

Affiliation:

1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

2. Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Huazhong University of Science and Technology, Wuhan 430030, China

3. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

4. Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

5. Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

6. Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital Huazhong University of Science and Technology, Wuhan 430022, China

7. Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

8. Departments of Diagnostic Radiology and Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore

9. Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117597, Singapore

10. Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, and Nanomedicine Translational Research Program, National University of Singapore, 117597, Singapore

11. NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore

Funder

National Medical Research Council

Natural Science Foundation of Hubei Province

National University of Singapore

Fundamental Research Funds for the Central Universities

National Natural Science Fund for Excellent Young Scientists Fund Program

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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