Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety-Reference-Cited by-同舟云学术

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Published:2018-09-26 Issue:10 Volume:12 Page:9815-9829
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Van der Jeught Kevin¹^ORCID,De Koker Stefaan²,Bialkowski Lukasz¹,Heirman Carlo¹,Tjok Joe Patrick¹,Perche Federico³,Maenhout Sarah²,Bevers Sanne²,Broos Katrijn¹,Deswarte Kim⁴,Malard Virginie³,Hammad Hamida⁴,Baril Patrick³,Benvegnu Thierry⁵,Jaffrès Paul-Alain⁶,Kooijmans Sander A. A.⁷,Schiffelers Raymond⁷,Lienenklaus Stefan⁸,Midoux Patrick³,Pichon Chantal³,Breckpot Karine¹,Thielemans Kris¹

Affiliation:

1. Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Brussels 1090, Belgium

2. eTheRNA Immunotherapies NV, Niel 2845, Belgium

3. Centre de Biophysique Moléculaire, CNRS UPR 4301, University and Inserm, Orléans 45071, France

4. VIB Inflammation Research Center, UGent, Ghent 9052, Belgium

5. Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR6226, Rennes 35708, France

6. CEMA, CNRS UMR 6521, SFR148 ScInBioS, Université de Brest, Brest 29238, France

7. University Medical Center Utrecht, Universiteit Utrecht, Utrecht 3584, Netherlands

8. Hannover Medical School, Hannover 30625, Germany

Funder

Vlaamse Liga Tegen Kanker

Federaal Wetenschapsbeleid

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Stichting Tegen Kanker

Seventh Framework Programme

Fonds Germaine eisendrath - Dubois VZW

Integrated Project

Ministry of Health, Belgium

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.8b00966

Reference45 articles.

1. Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

2. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

3. Toll like receptor mediated immune stimulation can be visualized in vivo by [ 18 F]FDG-PET

4. Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

5. Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine

Cited by 111 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo;Biomaterials;2024-10

2. Lipid nanoparticle-based mRNA vaccines: a new frontier in precision oncology;Precision Clinical Medicine;2024-07-24

3. Emerging advances in delivery systems for mRNA cancer vaccines;Journal of Controlled Release;2024-06

4. Nanomaterials Boost CAR‐T Therapy for Solid Tumors;Advanced Healthcare Materials;2024-05-21

5. The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy;International Immunopharmacology;2024-05