Hierarchical Vitalization of Oligotyrosine in Mitigating Islet Amyloid Polypeptide Amyloidogenesis through Multivalent Macromolecules with Conformation-Restrained Nanobody Ligands

Author:

Xin Yanru1,Wang Sheng2,Liu Hui1,Ke Huichuan1,Tian Sidan1,Cao Yujuan1,Huang Yuanda2,Shang Yunhu2,Jia Haibo2,Su Li1,Yang Xiangliang1,Meng Fanling13ORCID,Luo Liang13ORCID

Affiliation:

1. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

2. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

3. Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Funder

Ministry of Science and Technology of the People's Republic of China

Huazhong University of Science and Technology

Natural Science Foundation of Hubei Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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