Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides-Reference-Cited by-同舟云学术

Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides

Published:2024-03-28 Issue:14 Volume:18 Page:10324-10340
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Wang Zixuan¹,Zhang Jiaxing¹^ORCID,Wang Yuefei¹²³^ORCID,Zhou Jialin¹,Jiao Xinhao¹,Han Mingshan¹,Zhang Xuelin¹,Hu Hailiang¹,Su Rongxin¹⁴²^ORCID,Zhang Yumiao¹⁵^ORCID,Qi Wei¹⁴²^ORCID

Affiliation:

1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China

2. Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin 300072, P. R. China

3. Beyonpep Biotechnology Limited, Tianjin 300110, P. R. China

4. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China

5. Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin 300072, P. R. China

Funder

Tianjin University

State Key Laboratory of Chemical Engineering

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.4c02400

Reference59 articles.

1. De novo design of tunable, pH-driven conformational changes

2. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

3. The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

4. Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

5. Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

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