Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction

Author:

Chen Qizhu1ORCID,Qian Qiuping2,Xu Hongbo3,Zhou Hao1,Chen Linjie1,Shao Nannan2,Zhang Kai4,Chen Tao1,Tian Haijun5,Zhang Zhiguang1,Jones Morgan6,Kwan Kenny Yat Hong7,Sewell Mathew6,Shen Shuying8,Wang Xiangyang1,Khan Moonis Ali9ORCID,Makvandi Pooyan101112,Jin Shengwei3,Zhou Yunlong2ORCID,Wu Aimin1

Affiliation:

1. Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

2. Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China

3. Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

4. Ninth People’s Hospital, Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

5. Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

6. Spine Unit, The Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham B31 2AP, U.K.

7. Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

8. Department of Orthopaedics, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China

9. Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

10. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang, China

11. Centre of Research Impact and Outcome, Chitkara University, Rajpura-140401, Punjab, India

12. Department of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai-600077, India

Funder

Wenzhou Municipal Science and Technology Bureau

Science and Technology Department of Zhejiang Province

Science and Technology Plan Project of Wenzhou Municipality

King Saud University

Medical Technology and Education of Zhejiang Province of China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Key Laboratory of Structural Malformations in Children of zhejiang Province

Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province

Wenzhou Public Welfare Science and Technology Project

Publisher

American Chemical Society (ACS)

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