Precise Photodynamic Therapy by Midkine Nanobody-Engineered Nanoparticles Remodels the Microenvironment of Pancreatic Ductal Adenocarcinoma and Potentiates the Immunotherapy

Author:

Qu Chengming12,Yuan Haitao3ORCID,Tian Ming12,Zhang Xiaodong4,Xia Peng12,Shi Guangwei5,Hou Rui3,Li Ji6,Jiang Haibo7,Yang Zhiyong12,Chen Tengxiang8,Li Zhijie3ORCID,Wang Jigang391011ORCID,Yuan Yufeng1212ORCID

Affiliation:

1. Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, P. R. China

2. Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Wuhan 430071, Hubei, P. R. China

3. Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital; First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong, P. R. China

4. Department of Medical Imaging, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics· Guangdong Province), Guangzhou 510630, Guangdong, P. R. China

5. Department of Neurosurgery & Medical Research Center, Shunde Hospital, Southern Medical University (The First People’ s Hospital of Shunde Foshan), Guangzhou 528300, Guangdong, P. R. China

6. Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands 6009, Western Australia, Australia

7. Department of Chemistry, The University of Hong Kong, Pok Fu Lam, Hong Kong 999077, P. R. China

8. Precision Medicine Research Institute of Guizhou Medical University, Affiliated Hospital of Guizhou Medical University, Guiyang 550009, Guizhou, P. R. China

9. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China

10. Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, P. R. China

11. State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, Henan, P. R. China

12. TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, Hubei, P. R. China

Funder

National Key Research and Development Program of China

Science and Technology Foundation of Shenzhen City

Basic and Applied Basic Research Foundation of Guangdong Province

China Postdoctoral Science Foundation

Natural Science Foundation of Shenzhen Municipality

Science, Technology and Innovation Commission of Shenzhen Municipality

State Administration of Traditional Chinese Medicine of the People's Republic of China

China Academy of Chinese Medical Sciences

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Program

Shenzhen Government

HUILAN Public Welfare

Shenzhen key Laboratory of Kidney Diseases

Shenzhen Medical Academy of Research and Translation

Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties

Distinguished Expert Project of Sichuan Province Tianfu Scholar

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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