Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix-Reference-Cited by-同舟云学术

Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix

Published:2022-03-08 Issue:3 Volume:16 Page:3895-3905
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Synakewicz Marie¹^ORCID,Eapen Rohan S.¹,Perez-Riba Albert¹,Rowling Pamela J. E.¹,Bauer Daniela²,Weißl Andreas²,Fischer Gerhard³,Hyvönen Marko³^ORCID,Rief Matthias²,Itzhaki Laura S.¹^ORCID,Stigler Johannes⁴

Affiliation:

1. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom†

2. Physik-Department, Technische Universität München, James-Franck-Straße 1, 85748 Garching, Germany

3. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, United Kingdom

4. Gene Center Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 München, Germany

Funder

AstraZeneca

Medical Research Council

Deutsche Forschungsgemeinschaft

European Cooperation in Science and Technology

Biotechnology and Biological Sciences Research Council

British Biochemical Society

LMU Center for Nanoscience CeNS

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.1c09162

Reference84 articles.

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4. Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs

5. Folding landscapes of ankyrin repeat proteins: experiments meet theory

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