A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

Author:

Ye Binglin12345,Hu Wenting123,Yu Guocan6ORCID,Yang Huang7,Gao Bingqiang12345,Ji Jian7ORCID,Mao Zhengwei127ORCID,Huang Feihe89ORCID,Wang Weilin12345,Ding Yuan12345

Affiliation:

1. Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China

2. Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China

3. Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, China

4. Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease, Zhejiang University, Hangzhou, Zhejiang 310009, China

5. The Second Affiliated Hospital of Zhejiang University Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, Zhejiang 310009, China

6. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

7. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China

8. Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China

9. Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, Zhejiang 311215, China

Funder

Zhejiang University

Key Research and Development Program of Zhejiang Province

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province

Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine

Publisher

American Chemical Society (ACS)

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