Single-Particle Spectroscopic Chromatography Reveals Heterogeneous RNA Loading and Size Correlations in Lipid Nanoparticles-Reference-Cited by-同舟云学术

Single-Particle Spectroscopic Chromatography Reveals Heterogeneous RNA Loading and Size Correlations in Lipid Nanoparticles

Published:2024-06-05 Issue:24 Volume:18 Page:15729-15743
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Li Sixuan¹²^ORCID,Hu Yizong¹³⁴^ORCID,Lin Jinghan¹⁴⁵,Schneiderman Zachary¹⁶,Shao Fangchi³^ORCID,Wei Lai²,Li Andrew³,Hsieh Kuangwen²^ORCID,Kokkoli Efrosini¹⁶^ORCID,Curk Tine⁵^ORCID,Mao Hai-Quan¹³⁴⁵^ORCID,Wang Tza-Huei¹²³^ORCID

Affiliation:

1. Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States

2. Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States

3. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, United States

4. Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, United States

5. Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States

6. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.4c02341

Reference61 articles.

1. The current landscape of nucleic acid therapeutics

2. Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

3. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

4. Nanotechnology-based strategies against SARS-CoV-2 variants

5. The clinical progress of mRNA vaccines and immunotherapies

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