Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release-Reference-Cited by-同舟云学术

Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release

Published:2019-03-26 Issue:4 Volume:13 Page:4049-4063
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Kong Chao¹,Li Yang²,Liu Zhengsheng¹,Ye Junxiao¹,Wang Zhaohui²,Zhang Ling¹,Kong Weijian¹,Liu Huiqin¹,Liu Chun¹,Pang Huanhuan³,Hu Zeping³,Gao Jinming²^ORCID,Qian Feng¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People’s Republic of China

2. Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States

3. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, People’s Republic of China

Funder

National Natural Science Foundation of China

Tsinghua University

Peking University

National Cancer Institute

Novagenesis Theraputix Limited

Beijing Advanced Innovation Center for Structural Biologys, Tsinghua University

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Link

https://pubs.acs.org/doi/pdf/10.1021/acsnano.8b08246

Reference73 articles.

1. Steward, B.; Wild, C.; Stewart, B.; Wild, C. World Cancer Report 2014 International Agency for Research on Cancer World Health Organization; International Agency for Research on Cancer, World Health Organization 2014.

2. Genetics and biology of pancreatic ductal adenocarcinoma

3. Pancreatic Adenocarcinoma

4. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

5. Drugging RAS: Know the enemy

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