Design and Synthesis of 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites-Reference-Cited by-同舟云学术

Design and Synthesis of 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites

Published:2013-12-02 Issue:23 Volume:56 Page:9709-9724
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Banala Ashwini K.¹,Zhang Peng¹,Plenge Per²,Cyriac George¹,Kopajtic Theresa³,Katz Jonathan L.³,Loland Claus Juul²,Newman Amy Hauck¹

Affiliation:

1. Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse−Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

2. Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark

3. Psychobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse−Intramural Research Program, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4014136

Reference39 articles.

1. SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

2. Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

3. Interaction of Antidepressants with the Serotonin and Norepinephrine Transporters

4. Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

5. Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter

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