Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design-Reference-Cited by-同舟云学术

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Published:2005-06-01 Issue:13 Volume:48 Page:4212-4215
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dymock Brian W.¹,Barril Xavier¹,Brough Paul A.¹,Cansfield Julie E.¹,Massey Andrew¹,McDonald Edward¹,Hubbard Roderick E.¹,Surgenor Allan¹,Roughley Stephen D.¹,Webb Paul¹,Workman Paul¹,Wright Lisa¹,Drysdale Martin J.¹

Affiliation:

1. Vernalis Ltd., Granta Park, Great Abington, Cambridge CB1 6GB, U.K., and Cancer Research U.K. Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050355z

Reference27 articles.

1. Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2. HSP90 as a new therapeutic target for cancer therapy: the story unfolds

3. Structure and in vivo function of Hsp90

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