1. Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ UK, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, 430071, PR China, and Nestlé Research Center, Lausanne, Nestec Ltd., Vers-Chez-Les-Blanc, 1000 Lausanne 26, Switzerland