Mapping the Binding Site of Melanocortin 4 Receptor Agonists: A Hydrophobic Pocket Formed by I3.28(125), I3.32(129), and I7.42(291) Is Critical for Receptor Activation-Reference-Cited by-同舟云学术

Mapping the Binding Site of Melanocortin 4 Receptor Agonists: A Hydrophobic Pocket Formed by I3.28(125), I3.32(129), and I7.42(291) Is Critical for Receptor Activation

Published:2006-01-12 Issue:3 Volume:49 Page:911-922
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hogan Kristine¹,Peluso Stephan¹,Gould Sandy¹,Parsons Ian¹,Ryan Dominic¹,Wu Lijun¹,Visiers Irache¹

Affiliation:

1. Departments of Molecular and Cellular Pharmacology, Medicinal Chemistry & Metabolic Diseases, Analytical Chemistry, and Computational Chemistry, Millennium Pharmaceuticals, Cambridge, Massachusetts 02446

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050780s

Reference50 articles.

1. Knockout Studies Defining Different Roles for Melanocortin Receptors in Energy Homeostasis

2. Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

3. Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity

4. Molecular Genetics of Human Obesity-Associated MC4R Mutations

5. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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