Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors-Reference-Cited by-同舟云学术

Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors

Published:2011-12-06 Issue:1 Volume:55 Page:68-83
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Flipo Marion¹²³⁴⁵,Desroses Matthieu¹²³⁴⁵,Lecat-Guillet Nathalie¹⁴⁵⁶⁷,Villemagne Baptiste¹²³⁴⁵,Blondiaux Nicolas¹⁴⁵⁶⁷,Leroux Florence¹²³⁴⁵,Piveteau Catherine¹²³⁴⁵,Mathys Vanessa⁸,Flament Marie-Pierre¹⁵⁹,Siepmann Juergen¹⁵⁹,Villeret Vincent¹¹⁰,Wohlkönig Alexandre¹¹,Wintjens René¹⁰¹²,Soror Sameh H.¹¹,Christophe Thierry¹³,Jeon Hee Kyoung¹³,Locht Camille¹⁴⁶⁷¹⁴,Brodin Priscille¹⁴⁶⁷¹⁴,Déprez Benoit¹²³⁴⁵,Baulard Alain R.¹⁴⁵⁶⁷,Willand Nicolas¹²³⁴⁵

Affiliation:

1. Université Lille Nord de France, F-59000 Lille, France

2. Biostructures and Drug Discovery, INSERM U761, F-59000 Lille, France

3. UDSL, F-59000 Lille, France

4. IPL, F-59019 Lille, France

5. PRIM, F-59000 Lille, France

6. INSERM U1019, F-59000 Lille, France

7. CNRS UMR8204, F-59021 Lille, France

8. Tuberculosis and Mycobacteria, Communicable and Infectious Diseases, Scientific Institute of Public Health (WIV-ISP), 1050 Brussel, Belgium

9. INSERM U1008, F-59000 Lille, France

10. IRI, USR 3078 CNRS, F-59658 Villeneuve d’Ascq, France

11. Structural Biology Brussels and Molecular and Cellular Interactions, VIB, 1050 Brussel, Belgium

12. Laboratoire de Chimie Générale, Institut de Pharmacie, Université Libre de Bruxelles, 1050 Brussel, Belgium

13. Biology of Intracellular Pathogens, Inserm Avenir, Institut Pasteur of Korea, 463-400 Gyeonggi-do, South Korea

14. Center for Infection and Immunity of Lille, F-59019 Lille, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200825u

Reference31 articles.

1. Are we really that good at treating tuberculosis?

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3. Tuberculosis and human immunodeficiency virus infection in developing countries

4. In South Africa, XDR TB and HIV Prove a Deadly Combination

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