Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Published:2006-10-27 Issue:24 Volume:49 Page:6954-6957
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Trotter B. Wesley¹,Nanda Kausik K.¹,Kett Nathan R.¹,Regan Christopher P.¹,Lynch Joseph J.¹,Stump Gary L.¹,Kiss Laszlo¹,Wang Jixin¹,Spencer Robert H.¹,Kane Stefanie A.¹,White Rebecca B.¹,Zhang Rena¹,Anderson Kenneth D.¹,Liverton Nigel J.¹,McIntyre Charles J.¹,Beshore Douglas C.¹,Hartman George D.¹,Dinsmore Christopher J.¹

Affiliation:

1. Departments of Medicinal Chemistry, Stroke and Neurodegeneration, Automated Biotechnology, Pain Research, and Drug Metabolism, Merck Research Laboratories, WP14-2, P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060927v

Reference24 articles.

1. Atrial Electrophysiology and Mechanisms of Atrial Fibrillation

2. Pharmacological Approaches in the Treatment of Atrial Fibrillation

3. New Antiarrhythmic Drugs for Prevention of Atrial Fibrillation

4. Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

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