Design and Synthesis of Imidazoline Derivatives Active on Glucose Homeostasis in a Rat Model of Type II Diabetes. 1. Synthesis and Biological Activities of N-Benzyl-N ‘-(arylalkyl)-2-(4‘,5‘-dihydro-1‘H-imidazol-2‘-yl)piperazines-Reference-Cited by-同舟云学术

Design and Synthesis of Imidazoline Derivatives Active on Glucose Homeostasis in a Rat Model of Type II Diabetes. 1. Synthesis and Biological Activities of N-Benzyl-N ‘-(arylalkyl)-2-(4‘,5‘-dihydro-1‘H-imidazol-2‘-yl)piperazines

Published:1997-11-01 Issue:23 Volume:40 Page:3793-3803
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rondu Frédéric¹,Le Bihan Gaëlle¹,Wang Xuan¹,Lamouri Aazdine¹,Touboul Estera¹,Dive Georges¹,Bellahsene Tounès¹,Pfeiffer Bruno¹,Renard Pierre¹,Guardiola-Lemaitre Béatrice¹,Manechez Dominique¹,Penicaud Luc¹,Ktorza Alain¹,Godfroid Jean-Jacques¹

Affiliation:

1. Laboratoire de Pharmacochimie Moléculaire and Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Université Paris 7-Denis Diderot, 2, place Jussieu, 75251 Paris Cedex, France, ADIR, 1, rue Carle Hebert, 92415 Courbevoie Cedex, France, IRI Servier, 6, place des Pleiades, 92415 Courbevoie Cedex, France, Centre d'Ingénierie des Protéines, Institut de Chimie, Université de Liège, Belgium, and UPRESA, CNRS 5018/-UPS, Toulouse, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9608624

Reference40 articles.

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2. Mechanism of Metformin Action in Non-Insulin-Dependent Diabetes

3. Hermann, L. S.; Melander, A. Biguanides: Basic aspects and clinical uses. InInternational Textbook of Diabetes Mellitus; Alberti, K. G. M. M., DeFronzo, R. A., Keen, H., Zimmet, P., Eds.; John Wiley & Sons Ltd. New York 1992, pp 773−795.

4. Campbell, I. W.Sulphonylureas and Metformin: Efficacy and Inadequacyin New Antidiabetic Drugs; Bailey, C. J., Flatt, P. R., Eds.; Smith-Gordon: London, 1990, pp 33−51.

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