Fundamental Reaction Pathway and Free Energy Profile for Hydrolysis of Intracellular Second Messenger Adenosine 3′,5′-Cyclic Monophosphate (cAMP) Catalyzed by Phosphodiesterase-4-Reference-Cited by-同舟云学术

Fundamental Reaction Pathway and Free Energy Profile for Hydrolysis of Intracellular Second Messenger Adenosine 3′,5′-Cyclic Monophosphate (cAMP) Catalyzed by Phosphodiesterase-4

Published:2011-10-05 Issue:42 Volume:115 Page:12208-12219
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Chen Xi¹²,Zhao Xinyun³²,Xiong Ying²,Liu Junjun²,Zhan Chang-Guo²

Affiliation:

1. Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, People's Republic of China

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536, United States

3. College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, Hubei 430074, People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp205509w

Reference42 articles.

1. Purification and Properties of Periplasmic 3’:5’-Cyclic Nucleotide Phosphodiesterase

2. Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

3. Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity

4. Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases*

5. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

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