Conjugation of PolyPEG to Interferon Alpha Extends Serum Half-Life while Maintaining Low Viscosity of the Conjugate-Reference-Cited by-同舟云学术

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Conjugation of PolyPEG to Interferon Alpha Extends Serum Half-Life while Maintaining Low Viscosity of the Conjugate

Published:2015-02-18 Issue:3 Volume:26 Page:452-459
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Podobnik B.¹,Helk B.²,Smilović V.¹,Škrajnar Š.¹,Fidler K.¹,Jevševar S.¹,Godwin A.³,Williams P.⁴

Affiliation:

1. Sandoz Biopharmaceuticals, Mengeš, Lek Pharmaceuticals d.d., Kolodvorska 27, SI-1234 Mengeš, Slovenia

2. Novartis Pharma AG, CH-4056 Basel, Switzerland

3. PolyTherics Ltd, Babraham Research Campus, Babraham, Cambridge CB22 3AT, United Kingdom

4. PolyTherics Ltd, Unit 4, Vanguard Centre, University of Warwick Science Park, Coventry, CV4 7EZ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc500523t

Reference59 articles.

1. Peptide and protein PEGylation

2. Chemistry for peptide and protein PEGylation

3. PEGylation, successful approach to drug delivery

4. State of the art in PEGylation: The great versatility achieved after forty years of research

5. Receptor-Fc fusion therapeutics, traps, and MIMETIBODY™ technology

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