A Potent, Covalent Inhibitor of Orotidine 5‘-Monophosphate Decarboxylase with Antimalarial Activity-Reference-Cited by-同舟云学术

A Potent, Covalent Inhibitor of Orotidine 5‘-Monophosphate Decarboxylase with Antimalarial Activity

Published:2007-02-10 Issue:5 Volume:50 Page:915-921
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bello Angelica M.¹,Poduch Ewa¹,Fujihashi Masahiro¹,Amani Merhnaz¹,Li Yan¹,Crandall Ian¹,Hui Raymond¹,Lee Ping I.¹,Kain Kevin C.¹,Pai Emil F.¹,Kotra Lakshmi P.¹

Affiliation:

1. Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4 Canada, Departments of Pharmaceutical Sciences and Chemistry, University of Toronto, Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada, Structural Genomics Consortium, University of Toronto, Toronto, Canada, Departments of Medical Biophysics, Biochemistry, and Molecular and...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060827p

Reference34 articles.

1. Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

2. Equilibrium of Formation of the 6-Carbanion of UMP, a Potential Intermediate in the Action of OMP Decarboxylase

3. The Rate of Spontaneous Decarboxylation of Amino Acids

4. Computer simulations of enzyme catalysis: Finding out what has been optimized by evolution

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