Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ETA Antagonist (A-216546)-Reference-Cited by-同舟云学术

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ETA Antagonist (A-216546)

Published:1998-07-28 Issue:17 Volume:41 Page:3261-3275
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Gang¹,Henry, Kenneth J.¹,Szczepankiewicz Bruce G.¹,Winn Martin¹,Kozmina Natasha S.¹,Boyd Steven A.¹,Wasicak James¹,von Geldern Thomas W.¹,Wu-Wong Jinshyun R.¹,Chiou William J.¹,Dixon Douglas B.¹,Nguyen Bach¹,Marsh Kennan C.¹,Opgenorth Terry J.¹

Affiliation:

1. Metabolic Disease Research, Cancer Research, and Drug Analysis Department, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980217s

Reference34 articles.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells

2. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

3. Endothelins: multifunctional renal peptides.

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