Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels-Reference-Cited by-同舟云学术

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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

Published:2013-03-20 Issue:6 Volume:4 Page:930-939
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Miyata Yoshinari,Li Xiaokai,Lee Hsiu-Fang,Jinwal Umesh K.¹,Srinivasan Sharan R.,Seguin Sandlin P.²,Young Zapporah T.,Brodsky Jeffrey L.²,Dickey Chad A.¹,Sun Duxin,Gestwicki Jason E.

Affiliation:

1. Department of Molecular Medicine, University of South Florida, Tampa, Florida, United States

2. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/cn300210g

Reference44 articles.

1. Neurodegenerative Tauopathies

2. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

3. Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

4. Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport

5. Proteolytic processing of tau

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