High Level QM/MM Modeling of the Formation of the Tetrahedral Intermediate in the Acylation of Wild Type and K73A Mutant TEM-1 Class A β-Lactamase-Reference-Cited by-同舟云学术

High Level QM/MM Modeling of the Formation of the Tetrahedral Intermediate in the Acylation of Wild Type and K73A Mutant TEM-1 Class A β-Lactamase

Published:2009-09-30 Issue:43 Volume:113 Page:11984-11994
ISSN:1089-5639
Container-title:The Journal of Physical Chemistry A
language:en
Short-container-title:J. Phys. Chem. A

Author:

Hermann Johannes C.¹,Pradon Juliette¹,Harvey Jeremy N.¹,Mulholland Adrian J.¹

Affiliation:

1. Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K., and Roche Palo Alto LLC, 3431 Hillview Ave, Palo Alto, California 94304

Publisher

American Chemical Society (ACS)

Subject

Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp9037254

Reference104 articles.

1. Penicillin resistance: the chemistry of .beta.-lactamase inhibition

2. Page, M. I.InThe chemistry of beta-lactams;Page, M. I., Ed.Blackie:Glasgow, 1992; p79−100.

3. PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS

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