Photodegradation of Human Growth Hormone: A Novel Backbone Cleavage between Glu-88 and Pro-89
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States
2. Late Stage Pharmaceutical Development, Genentech, S. San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp400128j
Reference58 articles.
1. Protect from Light: Photodegradation and Protein Biologics
2. Identification of a Single Tryptophan Residue as Critical for Binding Activity in a Humanized Monoclonal Antibody against Respiratory Syncytial Virus
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4. Photodegradation mechanism and reaction kinetics of recombinant human interferon-α2a
5. The effect of low intensity ultraviolet-C light on monoclonal antibodies
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