Stereoselective Synthesis of (S)-3-(Methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile

Author:

Lall Manjinder S.1,Hoge Garrett2,Tran Tuan P.1,Kissel William3,Murphy Sean T.4,Taylor Clarke5,Hutchings Kim6,Samas Brian1,Ellsworth Edmund L.7,Curran Timothy8,Showalter H. D. Hollis9

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

2. Dr. Reddy’s, Cambridge, Cambridgeshire CB40PE, U.K.

3. Ironwood Pharmaceuticals, Cambridge, Massachusetts 02142, United States

4. Takeda California, San Diego, California 92121, United States

5. Lycera Corp., Ann Arbor, Michigan 48109, United States

6. AstraZeneca, Waltham, Massachusetts 02451, United States

7. Pfizer Worldwide Research and Development, Portage Street, Kalamazoo, Michigan 49007, United States

8. Vertex Pharmaceuticals, Cambridge, Massachusetts 02139, United States

9. University of Michigan, Ann Arbor, Michigan 48109, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference51 articles.

1. aEllsworth, E. L., Taylor, C. B., Murphy, S. T., Rauckhorst, M. R., Starr, J. T., Hutchings, K. M., Limberakis, C., and Hoyer, D. W.Preparation of quinolone antibacterial agents. WO 2005049602 A1, June 2, 2005.

2. The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents

3. Resistance drives antibacterial drug development

4. Antibiotic resistance and its cost: is it possible to reverse resistance?

5. New advances in antibiotic development and discovery

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