Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)-Reference-Cited by-同舟云学术

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

Published:2014-03-24 Issue:7 Volume:57 Page:3053-3074
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jansen Koen¹,Heirbaut Leen¹,Verkerk Robert²,Cheng Jonathan D.³,Joossens Jurgen¹,Cos Paul⁴,Maes Louis⁴,Lambeir Anne-Marie²,De Meester Ingrid²,Augustyns Koen¹,Van der Veken Pieter¹

Affiliation:

1. Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

2. Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

3. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, United States

4. Laboratory of Microbiology, Parasitology, and Hygiene, Departments of Pharmaceutical Sciences and Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500031w

Reference43 articles.

1. Structural and Kinetic Analysis of the Substrate Specificity of Human Fibroblast Activation Protein α

2. Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis

3. Fibroblast activation protein and chronic liver disease

4. Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α

5. Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis

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