Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)-Reference-Cited by-同舟云学术

Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Published:2014-08-04 Issue:15 Volume:57 Page:6632-6641
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hu Essa¹²,Chen Ning¹²,Bourbeau Matthew P.¹²,Harrington Paul E.¹²,Biswas Kaustav¹²,Kunz Roxanne K.¹²,Andrews Kristin L.¹²,Chmait Samer¹²,Zhao Xiaoning¹²,Davis Carl¹²,Ma Ji¹²,Shi Jianxia¹²,Lester-Zeiner Dianna¹²,Danao Jean¹²,Able Jessica¹²,Cueva Madelyn¹²,Talreja Santosh¹²,Kornecook Thomas¹²,Chen Hang¹²,Porter Amy¹²,Hungate Randall¹²,Treanor James¹²,Allen Jennifer R.¹²

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Molecular Structure and Characterization, §Department of Pharmacokinetics and Drug Metabolism, ∥Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 93012-1799, United States

2. Department of Molecular Structure and Characterization, #Department of Neuroscience, ∇Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500713j

Reference38 articles.

1. Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition

2. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

3. Immunohistochemical localization of PDE10A in the rat brain

4. Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

5. Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

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