Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation-Reference-Cited by-同舟云学术

Novel Inhibitors of Human Histone Deacetylase (HDAC) Identified by QSAR Modeling of Known Inhibitors, Virtual Screening, and Experimental Validation

Published:2009-01-30 Issue:2 Volume:49 Page:461-476
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Tang Hao¹,Wang Xiang S.¹,Huang Xi-Ping¹,Roth Bryan L.¹,Butler Kyle V.¹,Kozikowski Alan P.¹,Jung Mira¹,Tropsha Alexander¹

Affiliation:

1. Laboratory for Molecular Modeling, and Carolina Exploratory Center for Cheminformatics Research, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, Biophysics Training Program, Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, 833 South Wood Street, Chicago, Illinois 60612, and Department of Radiation Medicine, Georgetown University Medical...

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci800366f

Reference82 articles.

1. Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs

2. Histone Deacetylase: A Regulator of Transcription

3. Interaction of Histone Acetylases and Deacetylases In Vivo

4. A Mechanistic Approach to Anticancer Therapy: Targeting the Cell Cycle with Histone Deacetylase Inhibitors

5. Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

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