Structural Optimization and Biological Evaluation of 2-Substituted 5-Hydroxyindole-3-carboxylates as Potent Inhibitors of Human 5-Lipoxygenase-Reference-Cited by-同舟云学术

Structural Optimization and Biological Evaluation of 2-Substituted 5-Hydroxyindole-3-carboxylates as Potent Inhibitors of Human 5-Lipoxygenase

Published:2009-05-07 Issue:11 Volume:52 Page:3474-3483
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Karg Eva-Maria¹,Luderer Susann¹,Pergola Carlo¹,Bühring Ulrike¹,Rossi Antonietta¹,Northoff Hinnak¹,Sautebin Lidia¹,Troschütz Reinhard¹,Werz Oliver¹

Affiliation:

1. Department of Chemistry and Pharmacy, Chair of Pharmaceutical Chemistry, Friedrich Alexander University Erlangen, Schuhstrasse 19, D-91052 Erlangen, Germany, Department of Pharmaceutical Analytics, Pharmaceutical Institute, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, Italy, Institute for Clinical and Experimental Transfusion Medicine, University Medical Center Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900212y

Reference31 articles.

1. Leukotrienes

2. 5-Lipoxygenase: regulation of expression and enzyme activity

3. Therapeutic options for 5-lipoxygenase inhibitors

4. Development of 5-lipoxygenase inhibitors—lessons from cellular enzyme regulation

5. What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

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