1. Department of Molecular Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka 594-1101, Japan, Innovation Plaza Osaka, Japan Science and Technology Agency, 3-1-10 Technostage, Izumi, Osaka 594-1144, Japan, and Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan