Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine-Reference-Cited by-同舟云学术

Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine

Published:2000-09-14 Issue:22 Volume:43 Page:4071-4083
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Griffin Roger J.¹,Arris Christine E.¹,Bleasdale Christine¹,Boyle F. Thomas¹,Calvert A. Hilary¹,Curtin Nicola J.¹,Dalby Christine¹,Kanugula Sreenivas¹,Lembicz Nicola K.¹,Newell David R.¹,Pegg Anthony E.¹,Golding Bernard T.¹

Affiliation:

1. Department of Chemistry, Bedson Building, The University, Newcastle upon Tyne NE1 7RU, U.K.; Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.; AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.; and Departments of Cellular and Molecular Physiology and Pharmacology, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000961o

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