1. Contribution from the McGowan Institute for Regenerative Medicine, Suite 200, 100 Technology Drive, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, Department of Chemical and Petroleum Engineering, 1249 Benedum Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, Department of Bioengineering, 749 Benedum Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, and SACHEM Inc., 821 East Woodward Street, Austin, Texas 78704