Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway-Reference-Cited by-同舟云学术

Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway

Published:2012-06-11 Issue:24 Volume:134 Page:9999-10010
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Li Yunlang¹,Gridley Chelsea L.²,Jaeger Joachim²³,Sweasy Joann B.⁴,Schlick Tamar¹

Affiliation:

1. Department of Chemistry and Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, New York 10012, United States

2. Department of Biomedical Sciences, School of Public Health, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States

3. Division of Genetics, Wadsworth Center NYS-DOH, 150 New Scotland Avenue, Albany, New York 12208, United States

4. Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208040, New Haven, Connecticut 06520, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja300361r

Reference90 articles.

1. The DNA-damage response in human biology and disease

2. DNA Damage, Aging, and Cancer

3. Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function

4. The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

5. The E295K DNA Polymerase Beta Gastric Cancer-Associated Variant Interferes with Base Excision Repair and Induces Cellular Transformation

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