Discovery of Type II (Covalent) Inactivation of S-Adenosyl-l-homocysteine Hydrolase Involving Its “Hydrolytic Activity”: Synthesis and Evaluation of Dihalohomovinyl Nucleoside Analogues Derived from Adenosine-Reference-Cited by-同舟云学术

Discovery of Type II (Covalent) Inactivation of S-Adenosyl-l-homocysteine Hydrolase Involving Its “Hydrolytic Activity”: Synthesis and Evaluation of Dihalohomovinyl Nucleoside Analogues Derived from Adenosine

Published:1998-06-25 Issue:16 Volume:41 Page:3078-3083
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wnuk Stanislaw F.¹,Mao Yue¹,Yuan Chong-Sheng¹,Borchardt Ronald T.¹,Andrei Graciela¹,Balzarini Jan¹,De Clercq Erik¹,Robins Morris J.¹

Affiliation:

1. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700, Department of Biochemistry, University of Kansas, Lawrence, Kansas 66045, and Rega Institute for Medical Research, Katholieke Universiteit of Leuven, Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9801410

Reference25 articles.

1. 4',5'-Unsaturated-5'-fluoro adenosine nucleosides: potent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase

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